IRF2 Destabilizes Oncogenic KPNA2 to Modulate the Development of Osteosarcoma

<div>High expression of KPNA2 in osteosarcomas samples. (a) KPNA2 mRNA expression in OS and nontumor tissues based on data from GSE36001 dataset. (b) KPNA2 mRNA levels were detected in 25 pairs of OS samples and their adjacent normal samples by RT-qPCR. (c) Representative immunohistochemical (IHC) images of KPNA2 expression in OS tissues and normal tissues. (d) KPNA2 protein expression in 8 pairs of clinical OS samples were examined by western blotting. (e) KPNA2 expression in four OS cell lines and one normal hFOB1.19 cells using RT-qPCR and western blot assays. 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Journal of Oncology

fig1

Figure 1

Figure 1: IRF2 Destabilizes Oncogenic KPNA2 to Modulate the Development of Osteosarcoma 