SH3BGRL Suppresses Liver Tumor Progression through Enhanced ATG5-Dependent Autophagy

Figure 7

Relevance of SH3BGRL-ATG5 autophagy in liver cancer: (a) immunoblots of SH3BGRL and the indicated autophagy-related proteins in fresh liver tumor samples (T) and their adjacent normal tissues (N). β-actin was used as a loading control. (b) Immunohistochemistry of SH3BGRL and ATG5 from The Protein Atlas database (details are indicated in Supplementary Figure S1C). The bar is equal to 50 μm. (c) Immunohistochemistry of SH3BGRL, LC3, and ATG5 in the xenograft mouse tumors in Figure 6(c). Typical SH3BGRL-low and -high tumors are serially sliced. The bar is equal to 25 μm. (d) Schematic model of SH3BGRL-ATG5-autophagy signaling in liver cancer repression.

(a)

(b)

(c)

(d)