The Effects of circ_000558/miR-1225-5p/ARL4C on Regulating the Proliferation of Renal Cell Carcinoma Cells

Figure 5

ARL4C was a potential target gene of miR-1225-5p. (a) Venn diagram showing the overlapped potential target genes in TargetScan7.2, Targetprofiler, GSE16441, and GSE100666. The binding site between miR-1225-5p, ARL4C, and SEL1L3. (b, c) The expression profile of ARL4C (b) and SEL1L3 (c) in RCC samples by TCGA analysis. Blue, normal samples; red, tumor samples. (d, e) Effect of ARL4C (d) and SEL1L3 (e) expression levels on renal carcinoma patients’ survival; red, higher expression; blue, lower expression. (f) The relative luciferase intensity in 769-P and ACHN cells after wild-type of ARL4C (ARL4C-WT) or mutation type of ARL4C (ARL4C-Mut) and miR-1225-5p mimics (miR-mimics) cotransfect was tested by dual-luciferase reporter assay ( < 0.001).

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