Extracellular Volume Fraction Calculated Using Contrast-Enhanced Computed Tomography as a Biomarker of Oxaliplatin-Induced Sinusoidal Obstruction Syndrome: A Preliminary Histopathological Analysis

Figure 2

Preoperative computed tomography (CT) images from a 65-year-old woman with colorectal cancer liver metastasis after oxaliplatin-based chemotherapy. Oval regions of interest are placed and CT values are measured on the liver parenchyma and abdominal aorta in both precontrast (a) and equilibrium phase (b) images. On the basis of the hematocrit level (35.9%), ΔHU_liver (93.7 − 55.4 = 38.3 HU), and ΔHU_aorta (119.1 − 37.8 = 81.3 HU), the calculated extracellular volume fraction was (100 − 35.9) × 38.3/81.3 = 30.2%.