Circulating the HLA-DR+ T Cell Ratio Is a Prognostic Factor for Recurrence of Patients with Hepatocellular Carcinoma after Curative Surgery

Table 4

Comparisons of clinicopathological characteristics among 192 HCC patients with different AFP level groups.

Variables		AFP positivity (N)	AFP negativity (N)	χ^2	value
Age	<60 years	62	53	1.756	0.185
	≥60 years	34	43
Gender	Male	71	82	3.893	0.048
	Female	25	14
HbsAg	Positive	87	77	4.181	0.041
	Negative	9	19
Liver cirrhosis	Yes	60	54	0.777	0.378
	No	36	42
AST/ALT	<1	58	65	1.109	0.292
	≥1	38	31
GGT level	<45 U/L	61	68	0.369	0.543
	≥45 U/L	35	28
Child-Pugh class	A	93	94		1
	B	3	2
T cell ratio	<77%	75	75	0.000	1
	≥77%	21	21
CD4+ T cell ratio	<41.6%	60	64	0.364	0.546
	≥41.6%	36	32
CD8+ T cell ratio	<29.6%	61	65	0.369	0.543
	≥29.6%	35	31
HLADR+ T cell ratio	<5.8%	48	44	0.334	0.563
	≥5.8%	48	52
B cell ratio	<18.2%	70	84	6.431	0.011
	≥18.2%	26	12
NK cell ratio	<25.6%	85	83	0.190	0.663
	≥25.6%	11	13
Largest tumor size	<5 cm	70	72	0.108	0.742
	≥5 cm	26	24
Edmondson grade	I-II	47	69	10.541	0.001
	III-IV	49	27
Microvascular invasion	Yes	40	27	3.874	0.049
	No	56	69
Capsular invasion	Yes	37	33	0.360	0.549
	No	59	63
Prophylactic TACE after surgery	Yes	36	29	1.140	0.286
	No	60	67

AFP: alpha-fetoprotein; AFP positivity: AFP ≥ 20 ng/ml; AFP negativity: AFP < 20 ng/ml; AST: aspartate aminotransferase; ALT: alanine aminotransferase; GGT: gamma glutamyl transferase; TACE: transcatheter arterial chemoembolization.