Circulating the HLA-DR+ T Cell Ratio Is a Prognostic Factor for Recurrence of Patients with Hepatocellular Carcinoma after Curative Surgery

Table 7

Comparisons of clinicopathological characteristics among AFP-positive (≥20 ng/ml) HCC patients with different HLA-DR+ T cell ratio groups.

Variables		Total (N)	High HLADR+ T cell ratio (N)	Low HLADR+ T cell ratio (N)	χ^2	value
Age	<60 years	62	31	31	0.000	1
	≥60 years	34	17	17
Gender	Male	71	35	36	0.054	0.816
	Female	25	13	12
HbsAg	Positive	87	45	42		0.486
	Negative	9	3	6
Liver cirrhosis	Yes	60	29	31	0.178	0.673
	No	36	19	17
AST/ALT	<1	58	29	29	0.000	1.000
	≥1	38	19	19
GGT level	<45 U/L	61	31	30	0.045	0.832
	≥45 U/L	35	17	18
Child-Pugh grade	A	93	45	48		0.242
	B	3	3	0
T cell ratio	<77%	75	31	44	10.301	0.001
	≥77%	21	17	4
CD4+ T cell ratio	<41.6%	60	32	28	0.771	0.399
	≥41.6%	36	16	20
CD8+ T cell ratio	<29.6%	61	25	36	5.441	0.020
	≥29.6%	35	23	12
B cell ratio	<18.2%	70	40	30	5.275	0.022
	≥18.2%	26	8	18
NK cell ratio	<25.6%	85	45	40	2.567	0.109
	≥25.6%	11	3	8
Largest tumor size	<5 cm	70	32	38	1.899	0.168
	≥5 cm	26	16	10
Edmondson grade	I-II	47	23	24	0.042	0.838
	III-IV	49	25	24
Microvascular invasion	Yes	40	17	23	1.543	0.214
	No	56	31	25
Capsular invasion	Yes	37	19	18	0.044	0.834
	No	59	29	30
Prophylactic TACE after surgery	Yes	36	18	18	0.000	1.000
	No	60	30	30

AFP: alpha-fetoprotein; AST: aspartate aminotransferase; ALT: alanine aminotransferase; GGT: gamma glutamyl transferase; TACE: transcatheter arterial chemoembolization.