Circulating the HLA-DR+ T Cell Ratio Is a Prognostic Factor for Recurrence of Patients with Hepatocellular Carcinoma after Curative Surgery

Table 8

Comparisons of clinicopathological characteristics among AFP-negative (<20 ng/ml) HCC patients with different HLA-DR+ T cell ratio groups.

Variables		Total (N)	High HLADR+ T cell ratio (N)	Low HLADR+ T cell ratio (N)	χ^2	value
Age	<60 years	53	24	29	3.762	0.052
	≥60 years	33	28	15
Gender	Male	82	44	38	0.058	0.809
	Female	14	8	6
HbsAg	Positive	77	39	38	1.939	0.164
	Negative	19	13	6
Liver cirrhosis	Yes	54	32	22	1.289	0.256
	No	42	20	22
AST/ALT	<1	65	38	27	1.496	0.221
	≥1	31	14	17
GGT level	<45 U/L	68	39	29	0.953	0.329
	≥45 U/L	28	13	15
T cell ratio	<77%	75	39	36	0.648	0.421
	≥77%	21	13	8
CD4+ T cell ratio	<41.6%	64	34	30	0.084	0.772
	≥41.6%	32	18	14
CD8+ T cell ratio	<29.6%	65	29	36	7.397	0.007
	≥29.6%	31	23	8
B cell ratio	<18.2%	84	48	36	2.398	0.122
	≥18.2%	12	4	8
NK cell ratio	<25.6%	83	45	38	0.001	0.980
	≥25.6%	13	7	6
Largest tumor size	<5 cm	62	39	33	0.000	1.000
	≥5 cm	24	13	11
Edmondson grade	I-II	69	33	36	3.973	0.046
	III-IV	27	19	8
Microvascular invasion	Yes	27	15	12	0.029	0.864
	No	69	37	32
Capsular invasion	Yes	33	19	14	0.235	0.628
	No	63	33	30
Prophylactic TACE after surgery	Yes	29	13	16	1.460	0.227
	No	67	39	28

AFP: alpha-fetoprotein; AST: aspartate aminotransferase; ALT: alanine aminotransferase; GGT: gamma glutamyl transferase; TACE: transcatheter arterial chemoembolization.