Journal of Oncology

Research Article

Immunological Role of TP53 Somatic Mutation Classification in Human Cancers

Table 1

Correlation between TP53 expression and tumor microenvironment in 19 TP53-mut cancers.
Cancer typesTP53 classificationCor/-value
Stromal scoreImmune scoreEstimate score
BRCATruncating0.32/0.00030.3/0.00060.35/5.607e − 05
Nontruncating−0.4/7.994e − 090.07/0.34−0.2/0.02
BLCATruncating0.11/0.370.13/0.280.13/0.28
Nontruncating−0.05/0.56−0.2/0.07−0.1/0.2
COADTruncating0.09/0.510.16/0.220.13/0.31
Nontruncating−0.1/0.22−0.12/0.14−0.1/0.16
UCECTruncating0.13/0.350.03/0.850.08/0.6
Nontruncating−0.1/0.21−0.16/0.053−0.15/0.07
ESCATruncating0.08/0.58−0.08/0.590.0009/0.995
Nontruncating−0.01/0.92−0.21/0.06−0.11/0.31
GBMTruncating0.07/0.840.16/0.640.13/0.71
Nontruncating−0.3/0.07−0.32/0.053−0.33/0.04
HNSCTruncating0.3/0.00020.3/0.00020.32/7.295e − 05
Nontruncating0.1/0.180.04/0.560.08/0.29
LIHCTruncating0.45/0.0040.42/0.0070.47/0.002
Nontruncating0.15/0.210.24/0.0460.22/0.07
LGGTruncating0.14/0.32−0.14/0.32−0.01/0.94
Nontruncating−0.09/0.220.03/0.72−0.02/0.81
LUADTruncating0.27/0.0090.3/0.0050.31/0.003
Nontruncating−0.03/0.72−0.09/0.3−0.07/0.43
LUSCTruncating0.28/0.0020.25/0.0040.28/0.0014
Nontruncating−0.05/0.4−0.07/0.29−0.07/0.31
SKCMTruncating0.7/6.962e − 050.8/1.285e − 060.81/5.301e − 07
Nontruncating−0.09/0.62−0.15/0.39−0.13/0.45
OVTruncating0.15/0.16−0.006/0.950.08/0.47
Nontruncating−0.17/0.044−0.13/0.11−0.16/0.054
PAADTruncating0.32/0.090.47/0.01050.43/0.02
Nontruncating0.23/0.110.4/0.0040.34/0.02
PRADTruncating−0.08/0.750.08/0.76−0.005/0.98
Nontruncating−0.36/0.04−0.24/0.18−0.32/0.07
READTruncating0.36/0.060.26/0.180.34/0.08
Nontruncating−0.08/0.530.05/0.68−0.02/0.87
SARCTruncating0.52/0.0020.24/0.170.4/0.02
Nontruncating0.08/0.560.008/0.960.04/0.8
STADTruncating0.46/0.00010.27/0.030.4/0.0008
Nontruncating−0.01/0.92−0.06/0.61−0.04/0.74
UCSTruncating−0.61/0.04−0.13/0.7−0.43/0.17
Nontruncating−0.07/0.70.2/0.240.09/0.62
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