Research Article
Immunological Role of TP53 Somatic Mutation Classification in Human Cancers
Table 2
Significant correlation between TP53 expression and immune cell infiltration in 19 TP53-mut cancers.
| | Cell types | TP53 classification in 19 TP53-mut cancers (cor/-value) | | Truncating | Non-truncating |
| | Naive B cells | UCS: 0.65/0.02 | BLCA: 0.22/0.02 | | LGG: −0.23/0.002 | | LUAD: 0.18/0.03 |
| | Memory B cells | PAAD: 0.38/0.045 | NA |
| | Plasma cells | NA | LGG: −0.17/0.02 |
| | CD8 T cells | UCEC: 0.41/0.003 | BRCA: 0.22/0.002 | | SKCM: 0.45/0.02 | LIHC: 0.25/0.04 | | LUAD: 0.18/0.04 | | LUSC: 0.16/0.012 |
| | Naive CD4 T cells | HNSC: −0.2/0.04 | LGG: −0.18/0.02 | | OV: 0.37/0.0002 | READ: −0.3/0.02 |
| | Resting CD4 memory T cells | UCEC: −0.37/0.007 | BRCA: −0.2/0.007 | | PAAD: −0.4/0.009 | | PRAD: −0.4/0.04 |
| | Activated CD4 memory T cells | NA | BRCA: 0.3/1.872e − 05 | | GBM: −0.4/0.02 |
| | Follicular T helper cells | UCEC: 0.34/0.014 | BRCA: 0.3/1.876e − 05 | | OV: −0.24/0.02 | LGG: 0.16/0.03 | | STAD: 0.3/0.013 |
| | Regulatory T cells | LUSC: 0.22/0.011 | LUSC: 0.14/0.03 | | SKCM: 0.44/0.03 |
| | Gamma delta T cells | OV: 0.36/0.0003 | GBM: −0.33/0.04 | | LUAD: −0.22/0.009 | | PAAD: 0.65/3.765e − 07 | | PRAD: 0.4/0.02 |
| | Resting NK cells | BLCA: 0.31/0.013 | BRCA: −0.2/0.02 | | SKCM: −0.4/0.04 | READ: −0.3/0.03 | | OV: 0.34/0.0007 | SARC: 0.36/0.011 |
| | Activated NK cells | NA | COAD: 0.22/0.008 | | UCEC: −0.18/0.03 | | GBM: 0.49/0.002 | | LGG: 0.23/0.002 | | PRAD: 0.46/0.007 |
| | M0 macrophages | ESCA: 0.4/0.004 | UCEC: 0.21/0.014 | | LUSC: 0.22/0.02 | OV: 0.25/0.002 | | OV: 0.24/0.02 | | M1 macrophages | NA | BRCA: 0.14/0.045 | | BLCA: −0.2/0.047 | | PAAD: 0.3/0.03 | | PRAD: −0.43/0.013 |
| | M2 macrophages | BRCA: −0.25/0.005 | BRCA: −0.4/8.285e − 09 | | LGG: −0.31/0.03 | HNSC: 0.21/0.006 | | UCS: −0.6/0.046 | LUAD: −0.2/0.04 |
| | Resting dendritic cells | SKCM: 0.39/0.047 | NA |
| | Activated dendritic cells | BRCA: −0.23/0.008 | BRCA: 0.15/0.04 | | OV: −0.2/0.03 | HNSC: −0.2/0.014 | | PRAD: 0.6/0.008 |
| | Resting mast cells | COAD: 0.4/0.002 | BRCA: −0.4/3.896e − 08 | | LIHC: −0.25/0.04 | | SARC: −0.35/0.014 |
| | Activated mast cells | HNSC: −0.2/0.004 | BRCA: 0.21/0.003 | | LIHC: 0.37/0.02 | HNSC: −0.3/0.0001 | | LUAD: −0.2/0.03 | | LUSC: −0.1/0.047 | | UCS: 0.44/0.008 |
| | Eosinophils | NA | BRCA: 0.14/0.04 | | COAD: −0.2/0.04 | | LGG: 0.18/0.02 | | SKCM: −0.5/0.004 |
| | Neutrophils | HNSC: −0.2/0.02 | COAD: −0.22/0.006 | | STAD: −0.26/0.03 | HNSC: −0.2/0.008 | | LUAD: −0.2/0.012 | | LUSC: −0.22/0.0006 |
| | Monocytes | NA | COAD: −0.2/0.04 | | GBM: −0.36/0.03 | | OV: −0.25/0.002 | | STAD: −0.27/0.011 |
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indicates ; indicates ; indicates . NA indicates no statistical correlation. |
