Silencing UBQLN2 Enhances the Radiosensitivity of Esophageal Squamous Cell Carcinoma (ESCC) via Activating p38 MAPK

Figure 7

Knockdown of UBQLN2 enhanced the sensitivity of radiotherapy for esophageal squamous cell carcinoma (ESCC) xenografts. (a) The tumor volume of xenografts in the wild-type (WT), WT + irradiation (IR), UBQLN2 knockdown (UBQLN2-KD) +IR, and UBQLN2-KD + IR + SB203580 group. (b) The curves of xenograft growth overtime in WT, WT + IR, UBQLN2-KD + IR, and UBQLN2-KD + IR + SB203580 groups. (c) Immunohistochemical (IHC) analysis of p38 mitogen-activated protein kinases (MAPK), caspase-3, and Ki-67 on tissue sections of ESCC xenografts. The data are presented as the mean ± SD from six mice.  < 0.05 and  < 0.01 of analysis of variance (ANOVA).

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