Preoperative Cervical Lymph Node Metastasis Prediction in Papillary Thyroid Carcinoma: A Noninvasive Clinical Multimodal Radiomics (CMR) Nomogram Analysis

Table 2

Clinical characteristics of PTCs in the LNM and non-LNM groups in the training and validation cohorts.

Variable	Training cohort		Statistics	value	Validation cohort		Statistics	value
	Non-LNM	LNM			Non-LNM	LNM
Age (years)	47.90 ± 13.75	42.28 ± 13.09	1.876	0.061	46.12 ± 13.63	43.41 ± 13.44	0.62	0.539
Diameter (cm)	1.07 ± 0.97	1.20 ± 0.79	−2.097	0.036	0.97 ± 0.39	1.46 ± 0.65	−3.654	<0.001
Gender			0.316	0.574			2.25	0.318
Female	28 (68.29%)	39 (73.58%)			13 (76.47%)	13 (59.09%)
Male	13 (31.71%)	14 (26.42%)			4 (23.53%)	9 (40.91%)
Location			9.87	0.024			2.33	0.374
Right lobe	16 (39.02%)	18 (33.96%)			6 (35.29%)	8 (36.36%)
Left lobe	24 (58.54%)	23 (43.40%)			11 (64.71%)	11 (50.00%)
Isthmus	1 (2.44%)	4 (7.55%)			0 (0.00%)	3 (13.64%)
Bilateral	0 (0.00%)	8 (15.09%)
Number_of_lesions			7.08	0.057				0.495
1	36 (87.80%)	35 (66.04%)			17 (100%)	20 (90.91%)
2	4 (9.76%)	13 (24.53%)			0 (0.00%)	2 (9.09%)
3	0 (0.00%)	3 (5.66%)
4	1 (2.44%)	1 (1.89%)
5	0 (0.00%)	1 (1.89%)
Tumor margin on T1WC+			23.366	<0.001			46.667	<0.001
Well defined	27 (65.85%)	9 (16.98%)			14 (82.35%)	2 (9.09%)
Poorly defined	14 (34.15%)	44 (83.02%)			3 (17.65%)	20 (90.91%)
Thyroid contour protrusion sign on T1WC+			18.628	<0.001			101.333	<0.001
Absent	35 (85.37%)	22 (41.51%)			16 (94.12%)	3 (13.64%)
Present	6 (14.63%)	31 (58.49%)			1 (5.88%)	19 (86.36%)
Aspect ratio on US imaging							7.467	0.106
<1	34 (82.93%)	29 (54.72%)	8.323	0.004	16 (94.12%)	15 (68.18%)
>1	7 (17.07%)	24 (45.28%)			1 (5.88%)	7 (31.82%)
Microcalcification							5.143	0.025
Absent	27 (65.85%)	17 (32.08%)	10.593	0.001	12 (70.59%)	7 (31.82%)
Present	14 (34.15%)	36 (67.92%)			5 (29.41%)	15 (68.18%)
MOGONET	0.49 ± 0.01	0.51 ± 0.01	−6.609	<0.001	0.49 ± 0.01	0.51 ± 0.01	−3.569	<0.001

PTC, papillary thyroid carcinoma; LNM, lymph node metastasis. values of <0.05 were considered to indicate statistical significance.