LncRNA SNHG5 Suppresses Cell Migration and Invasion of Human Lung Adenocarcinoma via Regulation of Epithelial-Mesenchymal Transition

Figure 3

In vitro, SNHG5 inhibits LAD cell migration and invasion. (a) In the controls and LAD cell lines transfected with SNHG5, qRT-PCR analysis of SNHG5 was performed. Statistically, groups identified with various letters differ from one another.  < 0.01. (b) The MTS assay was performed in the control and LAD cell lines after transfection with SNHG5, (c, d) Transwell analyses were carried out in normal and SNHG5-overexpressing LAD cell lines; the original magnification was set at ×200. a, c:  < 0.05; b, d:  < 0.01. (e, f) Wound healing assay was conducted in the control and SNHG5-overexpressed LAD cell lines. Original magnification, ×100. The groups marked with “a” are statistically distinct.  < 0.05. (g) In the normal and A549 cells transfected with different siRNAs, qRT-PCR analysis of SNHG5 was performed. (h–j) MTS, Transwell, and wound healing analyses were conducted in controls and A549 tumor cells transfected with various siRNAs. a,b:  < 0.05.

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