The High Expression of p53 Is Predictive of Poor Survival Rather TP53 Mutation in Esophageal Squamous Cell Carcinoma

Figure 4

Type of somatic TP53 mutation in ESCC patients. (a) Distribution of TP53 mutations according to the affected exons. (b) Pie chart showing the proportion of the different types of somatic TP53 mutations. (c) Different types of mutations in the spectrum of TP53 mutations. (d) Graphical representation of the site of mutations in the coding sequence of TP53: red lollypop symbols in the lower panel representing missense mutations, blue, yellow, green, pink, and purple lollypop symbols in the upper panel representing others mutations (including nonsense, frameshift del, frameshift ins, silent, mixed type, respectively). Mutations occurring six or more are labeled: TA1, TA2, transactivation domain; DBD, DNA binding domain; TET, tetramerization domain. The figure was generated by the Illustrator for biological sequences version 1.0. (e) Summary of patients’ characteristics and alterations for TP53 and p53 protein in ESCC. Each column represents one patient sample. The phenotypic information in 316 ESCC patients is shown in the upper panel. Alterations for the TP53 gene and p53 protein are shown in the bottom panel.

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