The High Expression of p53 Is Predictive of Poor Survival Rather TP53 Mutation in Esophageal Squamous Cell Carcinoma
Table 1
Baseline characteristics of patients with ESCC.
Characteristics
The patients undergoing TP53 mutation analysis,
The patients with p53 IHC staining in TMA,
n = 316
(%)
n = 6028
(%)
Sex
Female
117
37.0
2107
35.0
Male
199
63.0
3921
65.0
Age at diagnosis (mean ± SD)
61.39 ± 8.18
60.92 ± 8.28
≤60
136
43.0
2917
48.4
>60
180
57.0
3111
51.6
High/low incidence area★
Low
64
20.3
2119
35.2
High
252
79.7
3909
64.8
Cigarette smoking
Negative
178
56.3
3160
52.4
Positive
136
43.1
2731
45.3
Missing
2
0.6
137
2.3
Alcohol consumption
Negative
184
58.2
4103
68.1
Positive
130
41.1
1791
29.7
Missing
2
0.6
134
2.2
Family history
Positive
131
41.5
2037
33.8
Negative
174
55.0
3875
64.3
Missing
11
3.5
116
1.9
Location
Cervical + upper
45
14.2
954
15.8
Middle
182
57.6
4092
67.9
Lower
68
21.5
879
14.6
Multiple
15
4.7
51
0.8
No record
6
1.9
52
0.9
Differentiation
Well differentiated
25
7.9
501
8.3
Moderate differentiated
195
61.7
3303
54.8
Poor differentiated
91
28.8
1935
32.1
No record
5
1.6
289
4.8
Pathological T stage
Tis + T1
18
5.7
205
3.4
T2
83
26.3
1466
24.3
T3
203
64.2
4242
70.4
T4
12
3.8
115
1.9
Pathological N stage
N0
174
55.1
3354
55.6
N1
142
44.9
2674
44.4
Pathological M stage
M0
308
97.5
5814
96.4
M1
8
2.5
214
3.6
UICC stage (6th)
0 + I
11
3.8
144
2.4
II
188
59.5
3691
61.2
III
109
34.2
1979
32.8
IV
8
2.5
214
3.6
Cancer embolus
Positive
21
6.6
256
4.2
Negative
295
93.4
5772
95.8
Type of treatment
Surgical
293
92.7
5006
83.0
Surgical + chemo
11
3.5
493
8.2
Surgical + radio
8
2.5
395
6.6
Surgical + chemo + radio
4
1.3
134
2.2
★areas with esophageal cancer incidence ≥50/100,000 are high-incidence area for esophageal cancer; on the contrary, areas with esophageal cancer incidence <50/100,000 is low-incidence area for esophageal cancer.
