The High Expression of p53 Is Predictive of Poor Survival Rather TP53 Mutation in Esophageal Squamous Cell Carcinoma

Table 2

Comparison of clinicopathologic features between mutation and wild-typeTP53 in patients with ESCC.

Characteristics	All patients,	Wild-typeTP53,		Mutation TP53,		value
	n = 316	n = 75	(%)	n = 241	(%)
Sex						0.736
Female	117	29	24.8	88	75.2
Male	199	46	23.1	153	76.9
Age at diagnosis (mean ± SD)						0.543
≤60	136	30	22.1	106	77.9
>60	180	45	25.0	135	75.0
High/low incidence area						0.551
Low	64	17	26.6	47	73.4
High	252	58	23.0	194	77.0
Cigarette smoking						0.277
Negative	178	46	25.8	132	74.2
Positive	136	28	20.6	108	79.4
Alcohol consumption						0.211
Negative	184	48	26.1	136	73.9
Positive	130	26	20.0	104	80.0
Family history						0.984
Negative	174	41	23.6	133	76.4
Positive	131	31	23.7	100	76.3
Location						0.904
Cervical + upper	45	12	26.7	33	73.3
Middle	182	42	23.1	140	76.9
Lower	68	15	22.1	53	77.9
Multiple	15	4	26.7	11	73.3
Differentiation						0.260
Well differentiated	25	3	12.0	22	88.0
Moderate differentiated	195	50	25.6	145	74.4
Poor differentiated	91	19	20.9	72	79.1
Pathological T stage						0.239
Tis + T1	18	7	38.9	11	61.1
T2	83	17	20.5	66	79.5
T3 + T4	215	51	23.7	164	76.3
Pathological N stage						0.130
N0	174	47	27.0	127	73.0
N1	142	28	19.7	114	80.3
Pathological M stage						1.000
M0	308	73	23.7	235	76.3
M1	8	2	25.0	6	75.0
UICC stage (6th)						0.053
0 + I	11	5	45.5	6	54.5
II	188	49	26.1	139	73.9
III + IV	117	21	17.9	96	82.1
Cancer embolus						0.590
Negative	295	69	23.4	226	76.6
Positive	21	6	28.6	15	71.4
Type of treatment						0.211
Surgical	293	72	24.6	221	75.4
Surgical + chemo/radio	23	3	13.0	20	87.0

the differences among categoric variables were analyzed using the Fisher exact test.