The High Expression of p53 Is Predictive of Poor Survival Rather TP53 Mutation in Esophageal Squamous Cell Carcinoma

Table 5

Association between TP53 mutation and p53 protein expression in 276 ESCC patients.

p53 protein expression	TP53 Mutation				TP53wild-type, n = 64
	Missense, n = 121	Nonsense, n = 36	Others, n = 55	Total
p53 high/low expression
p53 high expression	81	2	2	85	23
p53 low expression	40	34	53	127	41
p53 positive/negative expression
p53 expression (+)	117	11	10	138	38
p53 expression (−)	4	25	45	74	26

Note. When a missense mutation occurs, patients with multiple mutations are preferentially included in the missense mutation group. When a nonsense mutation occurs, the remaining patients are preferentially included in the nonsense mutation group.