The High Expression of p53 Is Predictive of Poor Survival Rather TP53 Mutation in Esophageal Squamous Cell Carcinoma

Table 6

Association between p53 protein expression and clinicopathologic features in patients with ESCC in tissue microarray.

Characteristics	All patients,	p53 protein expression				value
		Low expression,		High expression,
	n = 6028	n = 4209	(%)	n = 1819	(%)
Sex						0.525
Female	2107	1482	70.3	625	29.7
Male	3921	2727	69.5	1194	30.5
Age at diagnosis						0.492
≤60	2917	2049	70.2	868	29.8
>60	3111	2160	69.4	951	30.6
High/low incidence area						0.003
Low	2119	1531	72.3	588	27.7
High	3909	2678	68.5	1231	31.5
Cigarette smoking						0.393
Negative	3160	2217	70.2	943	29.8
Positive	2731	1888	69.1	843	30.9
Alcohol consumption						0.901
Negative	4103	2857	69.6	1246	30.4
Positive	1791	1250	69.8	541	30.2
Family history						0.615
Negative	3875	2703	69.8	1172	30.2
Positive	2037	1408	69.1	629	30.9
Location						0.667
Cervical + upper	954	678	71.1	276	28.9
Middle	4092	2842	69.5	1250	30.5
Lower	879	613	69.7	266	30.3
Mix	51	33	64.7	18	35.3
Differentiation						<0.001
Well differentiated	501	385	76.8	116	23.2
Moderate differentiated	3303	2350	71.1	953	28.9
Poor differentiated	1935	1280	66.1	655	33.9
Pathological T stage						0.335
Tis + T1	205	134	65.4	71	34.6
T2	1466	1022	69.7	444	30.3
T3	4242	2978	70.2	1264	29.8
T4	115	75	65.2	40	34.8
Pathological N stage						0.494
N0	3354	2354	70.2	1000	29.8
N1	2674	1855	69.4	819	30.6
Pathological M stage						0.930
M0	5814	4059	69.8	1755	30.2
M1	214	150	70.1	64	29.9
UICC stage (6th)						0.144
0 + I	144	89	61.8	55	38.2
II	3691	2600	70.4	1091	29.6
III	1979	1370	69.2	609	30.8
IV	214	150	70.1	64	29.9
Cancer embolus						0.028
Negative	5772	4046	70.1	1726	29.9
Positive	256	163	63.7	93	36.3
Type of treatment						0.596
Surgical	5006	3499	69.9	1507	30.1
Surgical + chemo	493	352	71.4	141	28.6
Surgical + radio	395	269	68.1	126	31.9
Surgical + chemo + radio	134	89	66.4	45	33.6