Advances in the Histone Acetylation Modification in the Oral Squamous Cell Carcinoma

Table 2

The major HDAC families.

Family	Dominant members	Characteristics
I	HDAC1, 2, 3, 8	Widely expressed in human cell lines and nuclear tissues
II	IIa: HDAC4, 5, 7, 9	Tissue specific expression, shuttling between nucleus and cytoplasm
	IIb: HDAC6, 10
III	Sirt1, 2, 3, 4, 5, 6, 7	NAD^+ dependent, with a very unique catalytic mechanism for deacetylation
IV	HDAC11	Deacetylate different histone sites, resulting in reduced substrate specificity