Advances in the Histone Acetylation Modification in the Oral Squamous Cell Carcinoma

Table 3

Histone acetylation sites and expression in OSCC.

Sites	Expression	Acetylase	Function	References
H2AK5	Hyperacetylation	Tip60	Hyperacetylation is associated with cancer promotion	[29]
H3K4	Hypoacetylation	P300/Tip60	Low acetylation level is positively correlated with malignancy	[28]
H3K9	Hypoacetylation	P300	CSC accumulation leads to hypoacetylation and promotes tumor; its absence is a hallmark of chemoresistance	[30, 31]
	Hyperacetylation		High acetylation expression detected in oral cancer	[29]
H3K14	Hyperacetylation	MOZ/MORF	P300-mediated hyperacetylation promotes tumor growth	[29]
H3K18	Hyperacetylation	P300	High acetylation levels are associated with poor prognosis	[28]
H3K27	Hyperacetylation	GCN5	Hyperacetylation enhances PD-L1 expression to promote tumor infiltration, metastasis, and recurrence	[32]
	Hyperacetylation		Hyperacetylation activates PLAC2 to promote tumor proliferation	[33]
H3K56	Hyperacetylation	P300/CPB	Hyperacetylation is associated with cancer promotion	[29]
H4K8	Hypoacetylation	P300/CPB	Hypoacetylation is associated with cancer promotion	[29]
H4K16	Hypoacetylation	hMOF/Tip60	Hypoacetylation is associated with cancer promotion	[29]
	Hyperacetylation		hMOF promotes acetylation to enhance oral cancer cell growth	[33]