Advances in the Histone Acetylation Modification in the Oral Squamous Cell Carcinoma

Table 4

Histone deacetylase and expression in OSCC.

Name	Expression	Function	References
HDAC2	High expression	Overexpressed in OSCC, resulting in protein HIF-1 α, resulting in increased invasion and migration of HNSCC	[39]
HDAC6	High expression	Send α-tubulin deacetylation, thus promoting the process of tumor metastasis development	[40, 41]
HDAC7	High expression	Activate c-myc and promote the proliferation of oral tumor cells	[42]
HDAC8	High expression	Inhibition of caspase activation and autophagy in OSCC	[42]
HDAC9	High expression	Promote tumor growth by targeting proapoptotic genes	[43]
SIRT1, 2, 3, 5, 7	Low expression	Inhibit tumor and prevent DNA damage and oxidative stress	[45, 46]