Advances in the Histone Acetylation Modification in the Oral Squamous Cell Carcinoma

Table 5

Antitumor effects of HDACis in OSCC.

Class	Name	Target	Mechanism	References
Hydroxamic acids	SAHA	HDAC I, HDAC II, HDAC IV	Induces hyperacetylation of H2A and H3 and inhibits tumor activity	[57]
			Upregulate E calcineurin and ErbB3, downregulate vimentin, EGFR and ErbB2, and enhance the antitumor effect of defibrotide	[58]
	TSA	HDAC I, HDAC II	Induced apoptosis of tumor cells in combination with PS-341	[59]
			Combine with ATRA to inhibit tumor growth	[60]
	LBH589	HDAC I, HDAC II, HDAC IV	Induce high acetylation of H3 and H4, inhibit tumor growth and induce apoptosis, and lead to G1 phase block	[61]
			Upregulate the expression of p21 and induce G2/M arrest and cancer cell apoptosis	[62]
Cyclopeptides	Apicidin	HDAC1, HDAC3	Competitive combination of HDAC and antitumor proliferation	[63]
			Increase the level of LC3-II and increase the apoptosis and autophagy of tumor cells	[64]
	FK228	HDAC1, HDAC2	Reduce Ki67 staining and inhibit tumor growth	[65]
			Induce high expression of hTERT and inhibit tumor growth	[66]
	Trapoxin	HDAC8	Inhibit tumor cell proliferation as a potential anticancer compound	[67]
Short-chain fatty acids	VPA	HDAC I, HDAC II	Promote H3, H4 acetylation and inhibit oncogene expression	[68]
			Increase G1 arrest and apoptosis of tumor cells	[69]
	PBA	HDAC I, HDAC II	Promote tumor cell apoptosis and inhibit EMT transformation	[70]
			Reduce TNF-α level and promote DNA repair	[71]
	NaBu	HDAC I, HDAC IIa	Induce cell cycle arrest, related to the increased expression of kip1	[72]
Benzamides	MS-275	HDAC I	Make tumor cells stagnate in G0/G1 phase, enhance H3 and H4 acetylation, and promote apoptosis	[73]
			Increase cisplatin cytotoxicity	[74]
			Inhibit tumor migration and invasion by activating mir-107 and miR-138	[75]
	MGCD0103	HDAC I, HDAC IV	Has better radiotherapy sensitization effect	[76]