Retinoblastoma-Binding Protein 5 Regulates H3K4 Methylation Modification to Inhibit the Proliferation of Melanoma Cells by Inactivating the Wnt/<i>β</i>-Catenin and Epithelial-Mesenchymal Transition Pathways

<div>RBBP5 positively regulated the expression of H3K4me3 and P16, and H3K4me3 could bind to the P16 promoter. (a–c) RBBP5 knockdown and (d–f) RBBP5 overexpression in A375 and A2058 cells, and the expression levels of H3K4me3 and p16 were detected by western blotting. GAPDH was used as an internal control. (g) ChIP was used to verify the interaction of H3K4me3 and p16. 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Journal of Oncology

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Figure 3

Figure 3: Retinoblastoma-Binding Protein 5 Regulates H3K4 Methylation Modification to Inhibit the Proliferation of Melanoma Cells by Inactivating the Wnt/<i>β</i>-Catenin and Epithelial-Mesenchymal Transition Pathways 

Figure 3 | Retinoblastoma-Binding Protein 5 Regulates H3K4 Methylation Modification to Inhibit the Proliferation of Melanoma Cells by Inactivating the Wnt/β-Catenin and Epithelial-Mesenchymal Transition Pathways 