Retinoblastoma-Binding Protein 5 Regulates H3K4 Methylation Modification to Inhibit the Proliferation of Melanoma Cells by Inactivating the Wnt/β-Catenin and Epithelial-Mesenchymal Transition Pathways

Figure 4

RBBP5 knockdown promoted the progression of melanoma in vitro. CCK8 assay was performed to measure the proliferation ability of RBBP5 knockdown in A375 (a) and A2058 (b) cells. Representative pictures (c) and quantification (d) of colony formation ability was shown in A375 and A2058 cells after RBBP5 knockdown. Representative pictures (e, f) and quantification (f-g) of the migration and invasion ability was shown in A375 and A2058 cells after RBBP5 knockdown. Data are represented as the mean ± SD of three independent experiments. ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001.