Retinoblastoma-Binding Protein 5 Regulates H3K4 Methylation Modification to Inhibit the Proliferation of Melanoma Cells by Inactivating the Wnt/<i>β</i>-Catenin and Epithelial-Mesenchymal Transition Pathways

<div>RBBP5 inhibited the progression of melanoma and arrested the cell cycle in in vitro. CCK8 assay was performed to measure the proliferation ability of RBBP5-overexpressing in A375 (a) and A2058 (b) cells. Representative pictures (c) and quantification (d) of colony formation ability was shown in A375 and A2058 cells after RBBP5-overexpressed. Representative pictures (e, h) and quantification (f, g, i, j) of the migration and invasion ability was shown in A375 and A2058 cells after RBBP5-overexpressed. FACS analysis of propidium iodide-stained cells was used to obtain cell cycle profiles, and flow cytometry was used to analyse the cell cycle in RBBP5-overexpressing A375 (k left, l) and A2058 (k right, m) cells. 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Journal of Oncology

fig5

Figure 5

Figure 5: Retinoblastoma-Binding Protein 5 Regulates H3K4 Methylation Modification to Inhibit the Proliferation of Melanoma Cells by Inactivating the Wnt/<i>β</i>-Catenin and Epithelial-Mesenchymal Transition Pathways 

Figure 5 | Retinoblastoma-Binding Protein 5 Regulates H3K4 Methylation Modification to Inhibit the Proliferation of Melanoma Cells by Inactivating the Wnt/β-Catenin and Epithelial-Mesenchymal Transition Pathways 