Research Article
The Role of Radiotherapy for Patients with Unresectable Locally Advanced Breast Cancer following Neoadjuvant Systemic Therapy
Table 1
Patient characteristics at time of primary diagnosis and comparison between DRT and NART subgroups.
| Parameters | Total | DRT (n = 45) | NART (n = 26) | | No. (%) | No. (%) | No. (%) |
| Median age (range) (years) | | 50 (26–74) | 48 (30–74) | 53 (26–72) | |
| Menopausal status | Pre/peri | 38 (53.5) | 25 (55.6) | 13 (50.0) | 0.640 | Post | 32 (45.1) | 19 (42.2) | 13 (50.0) | Male | 1 (1.4) | 1 (2.2) | 0 (0.0) |
| Laterality | Left | 37 (52.1) | 25 (55.6) | 12 (46.2) | 0.445 | Right | 34 (47.9) | 20 (44.4) | 14 (53.8) |
| cT | cT1 | 2 (2.8) | 2 (4.4) | 0 (0.0) | 0.002 | cT2 | 9 (12.7) | 8 (17.8) | 1 (3.8) | cT3 | 15 (21.1) | 14 (31.1) | 1 (3.8) | cT4 | 45 (63.4) | 21 (46.7) | 24 (92.3) | cT4d | 27 (38.0) | 13 (28.9) | 14 (53.8) |
| cN | cN0 | 3 (4.2) | 2 (4.4) | 1 (3.8) | 0.066 | cN1 | 14 (19.7) | 5 (11.1) | 9 (34.6) | cN2 | 17 (23.9) | 10 (22.2) | 7 (26.9) | cN3 | 37 (52.1) | 28 (62.2) | 9 (34.6) |
| Site of regional nodes | None | 3 (4.2) | 2 (4.4) | 1 (3.8) | 0.241 | ALN | 30 (42.3) | 16 (35.6) | 14 (53.8) | SCV | 1 (1.4) | 0 (0.0) | 1 (3.8) | ALN + SCV | 25 (35.2) | 19 (42.2) | 6 (23.1) | ALN + IMN | 9 (12.7) | 5 (11.1) | 4 (15.4) | ALN + SCV + IMN | 3 (4.2) | 3 (6.7) | 0 (0.0) |
| cM | cM0 | 62 (87.3) | 36 (80.0) | 26 (100.0) | 0.015 | cM1 (bone) | 9 (12.7) | 9 (20.0) | 0 (0.0) |
| Clinical TNM stage (pre-treatment) | IIIA | 3 (4.2) | 3 (6.7) | 0 (0.0) | 0.001 | IIIB | 27 (38.0) | 10 (22.2) | 17 (65.4) | IIIC | 32 (45.1) | 23 (51.1) | 9 (34.6) | IV | 9 (12.7) | 9 (20.0) | 0 (0.0) |
| Biologic subtype | Luminal A | 10 (14.1) | 8 (17.8) | 2 (7.7) | 0.290 | Luminal B | 15 (21.1) | 11 (24.4) | 4 (15.4) | HER2-overexpressed | 15 (21.1) | 10 (22.2) | 5 (19.2) | Triple-negative | 31 (43.7) | 16 (35.6) | 15 (57.7) |
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DRT = definitive radiotherapy; NART = neoadjuvant radiotherapy; ALN = axillary lymph nodes; SCV = supraclavicular; ICV = infraclavicular; IMN = internal mammary nodes.
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