Research Article
The Role of Radiotherapy for Patients with Unresectable Locally Advanced Breast Cancer following Neoadjuvant Systemic Therapy
Table 3
Tumor stage and clinical/pathological-complete response after treatment.
| | Parameters | Total (n = 71) | DRT (n = 45) | NART (n = 26) | | | No. (%) | No. (%) | No. (%) |
| | Pre-RT/post-NST | ycStage | 0-II | 8 (11.3) | 8 (17.8) | 0 (0.0) | 0.007 | | IIIA | 5 (7.0) | 3 (6.7) | 2 (7.7) | | IIIB | 29 (40.8) | 13 (28.9) | 16 (61.5) | | IIIC | 20 (28.2) | 12 (26.7) | 8 (30.8) | | IV | 9 (12.7) | 9 (20.0) | 0 (0.0) | | yc | ycT0 | 1 (1.4) | 1 (2.2) | 0 (0.0) | 0.547 | | ycN0 | 21 (29.6) | 14 (31.1) | 7 (26.9) | | ycCR | 2 (2.8) | 2 (4.4) | 0 (0.0) |
| | Post-RT | ycStage | 0-II | 35 (49.3) | 21 (46.7) | 14 (53.8) | 0.021 | | IIIA | 6 (8.5) | 2 (4.4) | 4 (15.4) | | IIIB | 8 (11.3) | 3 (6.7) | 5 (19.2) | | IIIC | 11 (15.5) | 8 (17.8) | 3 (11.5) | | IV | 11 (15.5) | 11 (24.4) | 0 (0.0) | | yc | ycT0 | 2 (2.8) | 1 (2.2) | 1 (3.8) | 0.558 | | ycN0 | 29 (40.8) | 17 (37.8) | 12 (46.2) | | ycCR | 11 (15.5) | 9 (20.0) | 2 (7.7) |
| | Post-surgery | ypStage | 0-II | — | — | 16 (61.5) | — | | IIIA | — | — | 4 (15.4) | | IIIB | — | — | 3 (11.5) | | IIIC | — | — | 3 (11.5) | | yp | ypT0 | — | — | 1 (3.8) | — | | ypN0 | — | — | 12 (46.2) | | ypCR | — | — | 5 (19.2) |
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DRT = definitive radiotherapy; NART = neoadjuvant radiotherapy; RT = radiotherapy; NST = neoadjuvant systemic therapy; yc/ypCR = post-neoadjuvant therapy clinical/pathological-complete response.
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