The Role of Purine Metabolism-Related Genes PPAT and IMPDH1 in the Carcinogenesis of Intrahepatic Cholangiocarcinoma Based on Metabonomic and Bioinformatic Analyses
Table 1
Baseline characteristics of intrahepatic cholangiocarcinoma (ICC) patients and normal.
Variables
ICC (n = 5)
Normal (n = 5)
value
Age (years)
62 (54–67)
58.0 (50–64)
0.421
Gender (male/female)
2/3 (40.0/60.0)
2/3 (40.0/60.0)
1.000
HBsAg (negative/positive)
4/1 (80.0/20.0)
0/5 (0.0/100.0)
0.010
Cirrhosis (no/yes)
3/2 (60.0/20.0)
0/5 (0.0/100.0)
0.114
WBC (109/L)
6.3 (3.5–9.5)
6.1 (4.1–8.6)
0.316
Hemoglobin (g/dL)
14.6 (11.2–19.1)
14.8 (12.8–19.8)
0.150
PLT (109/L)
194 (100–436)
178 (120–372)
0.285
PT (seconds)
12.2 (9.5–17.0)
12.2 (9.5–17.0)
0.153
TBIL (μmol/L)
11.2 (9.2–18.5)
7.9 (7.5–17.3)
0.147
ALB (g/L)
42.7 (31.8–53.1)
43.6 (38.5–54.9)
0.263
ALT (U/L)
40.1 (19.8–54.6)
23.8 (8.9–49.1)
0.129
AST (U/L)
35.1 (22.4–46.5)
23.0 (16.7–23.5)
0.017
CEA (ng/mL)
5.3 (0.3–6.1)
1.2 (0.5–2.1)
0.046
CA199 (U/mL)
336.7 (30.1–2501.2)
8.6 (8.2–12.2)
0.104
Tumor size (cm)
5.5 (4.0–6.4)
Tumor number (single/multiple)
4/1 (80.0/20.0)
Data are n (%) and ranges. Presented as median and ranges. ALT: alanine aminotransferase; AST: aspartate aminotransferase; ALB: albumin; CEA: carcinoembryonic antigen; CA199: carbohydrate antigen199; HBsAg: hepatitis B surface antigen; ICC: intrahepatic cholangiocarcinoma; PLT: platelet; PT: prothrombin time; WBC: white blood cell.
