Journal of Oncology

Research Article

Cell-Free DNA in Cerebrospinal Fluid Complements the Monitoring Value of Interleukin-10 in Newly Diagnosed Primary Central Nervous System Lymphoma

Table 1

Clinico-pathological characteristics of the ten newly diagnosed primary nervous system lymphoma patients.
PatientAgeGenderIELSGTumor locationHistology resultsCD20CD19CD10Bcl6Bcl2C-mycMum1P53Ki-67EBER ISHFlow cytometrySurgeryCSF IL-10 (pg/ml)
148M3Leptomeninges and nerve rootsB-NHL+++N/AN/AN/AN/AN/A60%N/AB-NHLN/A272.0
267M3Eyes, ventricular system, right frontal lobe, and left basal gangliaB-NHL++−N/AN/AN/AN/AN/A50%N/AB-NHL#Rescetion$72.5
362M3Left corpus callosum and left cerebellumDLBCL, GCB+N/A+++−+−70%N/A−Biopsy132.0
464M4Left frontal lobe, left basal ganglia, and corpus callosumDLBCL, non-GCB+N/A−++−++80%N/A−Rescetion72.0
561M2Sellar region and cavernous sinusDLBCL, GCB+N/A−++−−+70%−−Biopsy5.0
654F1Left basal ganglia, left cerebellum, and hypothalamusDLBCL, GCB+N/A++++++90%−−Biopsy918.0
749M1Left frontal lobeDLBCL, non-GCB+N/A−−++−−85%−−RescetionN/A
860F3Bilateral frontal lobesDLBCL, GCB+N/A++++N/A−85%−−Rescetion1000.0
924F1CerebellumDLBCL, GCB+++−−−−N/AN/A−−Rescetion95.4
1058M1Eyes and precentral gyrusB-NHLN/A+−N/AN/AN/AN/AN/A80%N/AB-NHL#Rescetion$32.5
M: male, F: female, IELSG: international extranodal lymphoma study group, DLBCL: diffused large B cell lymphoma, GCB: germinal center B cell, non-GCB: nongerminal center B cell, B-NHL: B cell nonhodgkin lymphoma, EBER ISH: the in situ hybridization of EBV-encoded RNA, CSF: cerebrospinal fluid, IL: interleukin, : flow cytometry of cerebrospinal fluid, #: flow cytometry of vitreous fluid, $: resection of vitreous body, −: negative, and +: positive.