Research Article
DNA Methylation Analysis of the SHOX2 and RASSF1A Panel Using Cell-Free DNA in the Diagnosis of Malignant Pleural Effusion
Table 1
Characteristics of all subjects.
| | | Total | Malignant | Nonmalignant |
| | Age (years) | | Mean ± SD | 57.9 ± 15.2 | 61.6 ± 9.3 | 53.0 ± 19.6 | | Range | 19∼82 | 33∼82 | 19∼82 | | Gender | | Male (n, %) | 67 (64.4%) | 36 (61.0%) | 31 (68.9%) | | Female (n, %) | 37 (35.6%) | 23 (39.0%) | 14 (31.1%) | | Smoking habit | | Smoker (n, %) | 45 (43.3%) | 31 (52.5%) | 14 (31.1%) | | Nonsmoker (n, %) | 59 (56.7%) | 28 (47.5%) | 31 (68.9%) | | MPE | | Lung cancer | — | 45 | — | | Ovary cancer | — | 1 | — | | Thymic squamous cell carcinoma | — | 1 | — | | Lymphoma | — | 1 | — | | Mesothelioma | — | 1 | — | | Adenoid cystadenocarcinoma | — | 1 | — | | BPE | | Tuberculosis | — | — | 37 | | Pulmonary infection | — | — | 5 | | Heart failure | — | — | 3 | | UPE | | Lung cancer | | 7 | | | Esophagus cancer | | 1 | | | Thymic squamous cell carcinoma | | 1 | |
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MPE = malignant pleural effusion; BPE = benign pleural effusion; UPE = pleural effusion with undefinite diagnosis.
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