DNA Methylation Analysis of the SHOX2 and RASSF1A Panel Using Cell-Free DNA in the Diagnosis of Malignant Pleural Effusion

Table 2

Performance of the PE-cfDNA methylation test for BPE and MPE.

	Sensitivity (%)		Specificity (%)		NPV (%)		PPV (%)		Cut-off score
	Value	95% CI	Value	95% CI	Value	95% CI	Value	95% CI
SHOX2	90.0	77.4–96.3	100.0	90.2–100.0	90.0	77.4–96.3	100.0	90.2–100.0	10.0
RASSF1A	62.0	47.2–75.0	100.0	90.2–100.0	70.3	57.4–80.8	100.0	86.3–100.0	13.0
TM	96.0	85.1–99.3	100.0	90.2–100.0	95.7	84.3–99.3	100.0	90.8–100.0	—

SHOX2: short stature homeobox 2; RASSF1A: RAS-associated domain family 1 subtype A. CI: confidence interval; PPV, positive predictive value; NPV, negative predictive value; and TM, total methylation.