Research Article
DNA Methylation Analysis of the SHOX2 and RASSF1A Panel Using Cell-Free DNA in the Diagnosis of Malignant Pleural Effusion
Table 3
Univariate analysis of clinical variables and malignant effusion.
| | Variables | n | SHOX2 methylation | value | RASSF1A methylation | value | Total methylation | value | | Negative | Positive | Negative | Positive | Negative | Positive |
| | Age (years) | | ≤50 | 5 | 2 | 3 | 0.018 | 1 | 4 | >0.05 | 0 | 5 | >0.05 | | >50 | 45 | 3 | 42 | 18 | 27 | 2 | 43 | | Sex | | Male | 27 | 3 | 24 | >0.05 | 8 | 19 | >0.05 | 1 | 26 | >0.05 | | Female | 23 | 2 | 21 | 11 | 12 | 1 | 22 | | Smoking habit | | Smoker | 24 | 1 | 23 | >0.05 | 6 | 18 | >0.05 | 0 | 24 | >0.05 | | Nonsmoker | 26 | 4 | 22 | 13 | 13 | 2 | 24 | | MPE | | Lung cancer | 45 | | | | | | | | | | | NSCLC | 42 | 4 | 38 | — | 16 | 26 | — | 1 | 41 | — | | SCLC | 3 | 0 | 3 | | 0 | 3 | | 0 | 3 | | | Ovarian cancer | 1 | 0 | 1 | — | 1 | 0 | — | 0 | 1 | — | | Thymic squamous cell carcinoma | 1 | 0 | 1 | — | 1 | 0 | — | 0 | 1 | — | | Lymphoma | 1 | 0 | 1 | — | 0 | 1 | — | 0 | 1 | — | | Mesothelioma | 1 | 1 | 0 | — | 1 | 0 | — | 1 | 0 | — | | Adenoid cystadenocarcinoma | 1 | 0 | 1 | — | 0 | 1 | — | 0 | 1 | — | | BPE | | Tuberculosis | 37 | 37 | 0 | — | 37 | 0 | — | 37 | 0 | — | | Pulmonary infection | 5 | 5 | 0 | — | 5 | 0 | — | 5 | 0 | — | | Heart failure | 3 | 3 | 0 | — | 3 | 0 | — | 3 | 0 | — |
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