Research Article
DNA Methylation Analysis of the SHOX2 and RASSF1A Panel Using Cell-Free DNA in the Diagnosis of Malignant Pleural Effusion
Table 4
Diagnostic performance of different markers.
| | | Sensitivity% (95% CI) | Specificity% (95% CI) | NPV% (95% CI) | PPV% (95% CI) | Cut-off score |
| | Total methylation | 96.0 (78.8–95.9) | 100.0 (90.2–100.0) | 83.3 (70.2–91.6) | 100.0 (91.3–100.0) | — | | CEA (ng/mL) | 48.9 (33.9–64.0) | 100.0 (89.8–100.0) | 65.2 (52.3–76.2) | 100.0 (81.5–100.0) | 6 | | NSE (ng/mL) | 17.8 (8.5–32.6) | 100.0 (89.8–100.0) | 53.8 (42.3–64.8) | 100.0 (59.8–100.0) | 40 | | Pro-GRP (ng/mL) | 11.1 (4.2–24.8) | 88.4 (74.1–95.6) | 48.7 (37.3–60.2) | 50.0 (20.1–79.9) | 80 | | SCC (ng/mL) | 0 (0–9.8) | 100.0 (89.8–100.0) | 48.9 (38.1–59.7) | — | 4 | | CYFRA21-1 (ng/mL) | 42.2 (28.0–57.8) | 97.7 (86.2–99.9) | 61.8 (49.1–73.0) | 95.0 (73.1–99.7) | 6 | | AFP (IU/mL) | 0 (0–15.0) | 100.0 (88.0–100.0) | 56.3 (43.3–68.4) | — | 5.8 | | CA-125 (IU/mL) | 78.6 (58.5–91.0) | 47.2 (30.8–64.3) | 73.9 (51.3–88.9) | 53.7 (37.6–69.0) | 35 | | CA-153 (IU/mL) | 46.4 (28.0–65.8) | 100.0 (88.0–100.0) | 70.6 (56.0–82.1) | 100 (71.7–100) | 34.5 | | CA-199 (IU/mL) | 21.4 (9.0–41.5) | 97.2 (83.8–99.9) | 61.4 (47.6–73.7) | 85.7 (42.0–99.2) | 39 |
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CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value.
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