Correlation of DEPDC5 rs1012068 and rs5998152 Polymorphisms with Risk of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

Table 1

Characteristics of the included studies and genotype distributions.

Study (year of publication)	Country	Ethnicity	n (cases), n (controls)	Cohort characteristics	Genotype			Allele		NOS score	Control source	Genotyping method	for HWE	Matched parameters
rs1012068					TT	TG	GG	T	G
Miki et al. [12]	Japan	Asian	922	HCV-related HCC	608	289	25	1505	339	8		Human610-quad		Age, sex, BMI
			2390	Chronic HCV infection	1886	470	34	4242	538		HB		0.446
Lange et al. [13]	Switzerland	Caucasian	64	HCV-related HCC	36	26	2	98	30	7		Allele-specific PCR		Sex
			1849	With chronic hepatitis C	987	727	135	2701	997		HB		0.943
Liu [14]	China	Asian	320	HBV-related HCC	157	134	29	448	192	8		PCR-RFLP		Age, sex
			320	With chronic hepatitis B	164	133	23	461	179		HB		0.573
Al-Anazi et al. [15]	Saudi Arabia	Asian	151	HCV-related HCC	65	77	9	207	95	7		INNO-LiPA HCV II		BMI
			574	With chronic hepatitis C	297	244	33	838	310		HB		0.061
Ma et al. [16]	China	Asian	308	HBV-related HCC	145	130	33	420	196	6		MALDI-TOF MS		-
			484	With chronic hepatitis B	286	169	29	741	227		HB		0.546
Hai et al. [17]	Japan	Asian	142	HCV-related HCC	97	40	5	234	50	6		TaqMan		-
			575	With chronic hepatitis C	412	151	12	975	175		HB		0.671
Zhang [18]	China	Asian	46	HCV-related HCC	24	18	4	66	26	8		MALDI-TOF MS		Age, BMI
			141	With chronic hepatitis C	82	51	8	215	67		HB		0.985
Liu et al. [19]	China	Asian	308	HBV-related HCC	145	130	33	420	196	6		MALDI-TOF MS		-
			217	With chronic hepatitis B	124	79	14	327	107		HB		0.767
El-Daly et al. [20]	Saudi Arabia	Asian	100	HCV-related HCC	23	49	28	95	105	8		TaqMan		Age, sex
			100	Healthy control	71	24	5	166	34		HB		0.135
Sharkawy et al. [21]	Australia	Caucasian	188	With chronic hepatitis C	102	65	21	269	107	8		TaqMan		Age, sex, BMI
			1501	HCV-related HCC	791	580	130	2162	840		HB		0.110
Hanan et al. [22]	Egypt	African	60	With chronic hepatitis C	27	30	3	84	36	6		TaqMan		-
			20	HCV-related HCC	6	7	7	19	21		HB		0.182
rs5998152					TT	TC	CC	T	C
Miki et al. [12]	Japan	Asian	212	HCV-related HCC	138	68	6	344	80	8		Human610-quad		Age, sex, BMI
			765	With chronic hepatitis C	624	135	6	1383	147		HB		0.658
Al-Anazi et al. [15]	Saudi Arabia	Asian	151	HCV-related HCC	64	78	9	206	96	7		INNO-LiPA HCV II		BMI
			574	With chronic hepatitis C	298	239	37	835	313		HB		0.233
Qiao et al. [23]	China	Asian	48	HCV-related HCC	24	19	5	67	29	8		MALDI-TOF MS		Age, sex, BMI
			109	With chronic hepatitis C	65	35	9	165	53		HB		0.183

Abbreviations: HB, hospital-based; HCV, hepatitis C virus; HBV, hepatitis B virus; HWE, Hardy-Weinberg equilibrium; NOS, Newcastle–Ottawa Scale; BMI, body mass index; -, not reported.