| | Genetic models | | Number of studies (references) | OR (95% CI) | Z ( value) | df ( value) | I2 (%) | Meta-analysis model |
| | rs1012068 | | Allelic model (G vs. T) | Overall | 11 [9–19] | 1.32 (1.04, 1.67) | 2.26 (0.02) | 10 (<0.001) | 86 | Random | | Asians | 8 [10–17] | 1.56 (1.22, 1.99) | 3.58 (<0.001) | 7 (<0.001) | 84 | Random | | HBV-related | 3 [11, 13, 16] | 1.34 (1.16, 1.54) | 4.05 (<0.001) | 2 (0.14) | 49 | Fixed | | HCV-related | 8 [9, 10, 12, 14, 15, 17–19] | 1.29 (0.91, 1.84) | 1.43 (0.15) | 7 (<0.001) | 90 | Random | | Recessive model (GG vs. TG + TT) | Overall | 11 [9–19] | 1.42 (0.96, 2.10) | 1.73 (0.08) | 10 (0.001) | 66 | Random | | Asians | 8 [10–17] | 1.82 (1.43, 2.30) | 4.94 (<0.001) | 7 (0.13) | 37 | Fixed | | HBV-related | 3 [11, 13, 16] | 1.62 (1.16, 2.26) | 2.86 (0.004) | 2 (0.61) | 0 | Fixed | | HCV-related | 8 [9, 10, 12, 14, 15, 17–19] | 1.26 (0.68, 2.32) | 0.73 (0.47) | 7 (<0.001) | 75 | Random | | Dominant model (GG + TG vs.TT) | Overall | 11 [9–19] | 1.43 (1.09, 1.87) | 2.58 (0.01) | 10 (<0.001) | 83 | Random | | Asian | 8 [10–17] | 1.67 (1.26, 2.22) | 3.53 (0.004) | 7 (<0.001) | 82 | Random | | HBV-related | 3 [11, 13, 16] | 1.39(1.16, 1.66) | 3.57 (<0.001) | 2 (0.16) | 45 | Fixed | | HCV-related | 8 [9, 10, 12, 14, 15, 17–19] | 1.44 (0.97, 2.14) | 1.82 (0.07) | 7 (<0.001) | 87 | Random | | Homozygous model (GG vs. TT) | Overall | 11 [9–19] | 1.61 (1.01, 2.57) | 1.98 (0.05) | 10 (<0.001) | 75 | Random | | Asians | 8 [10–17] | 2.21 (1.42, 3.43) | 3.51 (<0.001) | 7 (0.006) | 64 | Random | | HBV-related | 3 [11, 13, 16] | 1.82 (1.29, 2.56) | 3.44 (<0.001) | 2 (0.40) | 0 | Fixed | | HCV-related | 8 [9, 10, 12, 14, 15, 17–19] | 1.44 (0.70, 2.99) | 0.99 (0.32) | 7 (<0.001) | 81 | Random | | Heterozygous model (TG vs. TT) | Overall | 11 [9–19] | 1.39 (1.09, 1.79) | 2.62 (0.009) | 10 (<0.001) | 78 | Random | | Asians | 8 [10–17] | 1.57 (1.20, 2.04) | 3.32 (<0.001) | 7 (<0.001) | 77 | Random | | HBV-related | 3 [11, 13, 16] | 1.31 (1.08, 1.59) | 2.80 (0.005) | 2 (0.25) | 28 | Fixed | | HCV-related | 8 [9, 10, 12, 14, 15, 17–19] | 1.44 (1.01, 2.07) | 1.99 (0.05) | 7 (<0.001) | 83 | Random |
| | rs5998152 | | Allelic model (C vs. T) | Asians/HCV-related | 3 [10, 12, 20] | 1.56 (1.05, 2.33) | 2.18 (0.03) | 2 (0.02) | 75 | Random | | Recessive model (CC vs. TC + TT) | Asians/HCV-related | 3 [10, 12, 20] | 1.32 (0.77, 2.26) | 1.02 (0.31) | 2 (0.14) | 50 | Fixed | | Dominant model (CC + TC vs.TT) | Asians/HCV-related | 3 [10, 12, 20] | 1.82 (1.44, 2.30) | 5.05 (<0.001) | 2 (0.13) | 51 | Fixed | | Homozygous model (CC vs. TT) | Asians/HCV-related | 3 [10, 12, 20] | 1.62 (0.93, 2.82) | 1.72 (0.09) | 2 (0.14) | 49 | Fixed | | Heterozygous model (TC vs. TT) | Asians/HCV-related | 3 [10, 12, 20] | 1.82 (1.43, 2.31) | 4.89 (<0.001) | 2 (0.24) | 30 | Fixed |
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