Expression of Th1/2/17 Cytokines in CML with or without Pulmonary Bacterial and Fungal Coinfection
Table 3
Expression of cytokines in different types of infection.
Parameter (pg/ml)
A: healthy group (n = 53)
B: no infection (n = 172)
C: bacterial lung infection (n = 65)
D: bacterial and fungal infections of the lungs (n = 16)
E: HBV infection (n = 19)
(A vs. B)
(B vs. C)
(B vs. D)
(B vs. E)
(C vs. D)
IL-4
2.04 (1.20–2.64)
3.10 (1.77–4.60)
4.52 (2.28–7.43)
3.54 (2.07–6.52)
3.42 (2.08–4.20)
<0.0001
0.0051
0.2431
0.9129
0.6351
IL-5
2.92 (2.34-3.42
1.92 (1.16–2.45)
3.01 (1.89–3.52)
1.92 (1.42–3.61)
1.62 (1.09–2.82)
<0.0001
<0.0001
0.3489
0.7595
0.3077
IL-6
6.00 (4.87–7.27)
5.56 (3.03–7.75)
19.00 (8.16–64.29)
34.08 (3.94–111.36)
3.37 (1.80–11.93)
0.0563
<0.0001
0.0016
0.3103
0.9574
IL-8
5.81 (3.96–7.92)
6.15 (3.70–10.99)
20.36 (11.80–89.39)
28.57 (8.28–82.06)
7.83 (4.03–13.81)
0.2536
<0.0001
<0.0001
0.4085
0.9244
IL-10
3.61 (2.90–4.10)
3.70 (2.41–5.26)
5.53 (4.20–7.94)
6.07 (3.43–50.37)
3.91 (2.12–4.98)
0.7391
<0.0001
0.0011
0.8320
0.2402
IL-12p70
3.14 (2.87–3.38)
4.08 (2.93–5.04)
4.59 (3.33–5.67)
4.07 (3.64–5.81)
3.80 (1.73–5.16)
0.0000
0.0476
0.545
0.4160
0.7219
IL-1β
1.27 (0.93–1.65)
1.82 (1.19–2.35)
2.05 (1.58–3.03)
1.91 (1.22–2.58)
1.22 (0.97–2.59)
0.0003
0.0168
0.5989
0.2377
0.4302
IL-2
2.60 (1.93–3.18)
2.88 (1.78–4.52)
3.51 (2.52–6.01)
3.45 (2.24–6.70)
2.14 (0.75–3.51)
0.1201
0.0137
0.1710
0.0516
0.9433
IFN-γ
3.04 (2.01–3.46)
2.31 (1.35–3.44)
2.95 (2.09–4.22)
2.46 (1.84–3.41)
1.75 (1.47–3.85)
0.0121
0.0014
0.4408
0.9008
0.2086
TNF-α
3.66 (2.77–5.00)
2.36 (1.35–3.44)
3.28 (2.42–4.72)
3.28 (1.64–5.50)
2.59 (1.45–4.51)
<0.0001
<0.0001
0.0523
0.4337
0.9811
TNF-β
3.12 (2.77–3.60)
2.29 (1.25–3.33)
3.18 (2.10–4.06)
2.97 (1.95–3.73)
2.86 (0.98–3.38)
<0.0001
0.0004
0.0808
0.7628
0.6352
IL-17A
2.17 (1.56–3.46)
1.88 (1.28–2.87)
2.40 (1.21–4.41)
2.41 (1.49–3.83)
1.90 (1.06–4.82)
0.1170
0.0351
0.1914
0.5831
0.9716
IL-17F
4.30 (3.90–5.38)
2.76 (1.47–4.41)
3.73 (2.59–5.05)
3.47 (2.87–5.03)
1.86 (1.00–4.38)
<0.0001
0.0011
0.0728
0.2620
0.8125
IL-22
1.02 (0.73–1.41)
1.38 (0.77–2.16)
2.06 (1.25–3.21)
1.82 (1.07–2.31)
1.05 (0.45–1.62)
0.0110
0.0023
0.3006
0.1697
0.2857
The difference in the expression of cytokines between the patient’s lungs with bacterial infection and without infection was detected by the Mann–Whitney U test. indicates a statistical difference.
