Association of LAMA1 Single-Nucleotide Polymorphisms with Risk of Esophageal Squamous Cell Carcinoma among the Eastern Chinese Population

Table 3

Association between LAMA1 single-nucleotide polymorphism and esophageal squamous cell carcinoma while controlling age and gender

Locus	Genotype	ESCC case	Control	Codominant model		Dominant model		Recessive model		Additive model		Multiplicative model
				Or (95%CI)	value	Or (95% CI)	value	Or (95% CI)	value	Or (95% CI)	value	Or (95% CI)	value
rs62081531	G/G	729 (69.9)	765 (66.9)	Ref		0.830 (0.691–0.997)	0.046	0.968 (0.606–1.545)	0.891	0.870 (0.743–1.017)	0.081	0.866 (0.739–1.015)	0.076
	G/A	261 (25.0)	334 (29.2)	0.820 (0.677–0.993)	0.042
	A/A	34 (3.3)	39 (3.4)	0.915 (0.571–1.465)	0.711
rs621993	G/G	704 (67.5)	777 (68.0)	Ref		0.981 (0.818–1.177)	0.839	1.114 (0.682–1.818)	0.666	0.997 (0.852–1.167)	0.970	0.997 (0.851–1.167)	0.970
	G/A	288 (27.6)	328 (28.7)	0.969 (0.803–1.17)	0.744
	A/A	33 (3.2)	33 (2.9)	1.104 (0.674–1.807)	0.695
rs539713	A/A	525 (50.3)	595 (52.1)	Ref		1.044 (0.881–1.236)	0.621	0.805 (0.576–1.124)	0.202	0.991 (0.866–1.135)	0.900	0.992 (0.868–1.133)	0.902
	G/A	436 (41.8)	456 (39.9)	1.084 (0.909–1.292)	0.371
	G/G	64 (6.1)	87 (7.6)	0.834 (0.591–1.175)	0.299
rs566655	T/T	738 (70.8)	832 (72.8)	Ref		1.057 (0.875–1.277)	0.563	1.340 (0.736–2.441)	0.338	1.071 (0.904–1.268)	0.430	1.070 (0.904–1.266)	0.432
	T/G	263 (25.2)	286 (25.0)	1.037 (0.853–1.259)	0.717
	G/G	24 (2.3)	20 (1.7)	1.353 (0.741–2.469)	0.325
rs73938538	A/A	829 (79.5)	891 (78.0)	Ref		0.844 (0.684–1.042)	0.115	0.854 (0.373–1.957)	0.710	0.857 (0.706–1.042)	0.122	0.859 (0.707–1.042)	0.124
	C/A	184 (17.6)	234 (20.5)	0.845 (0.682–1.048)	0.125
	C/C	10 (1.0)	13 (1.1)	0.827 (0.361–1.896)	0.653
rs607230	T/T	49 (4.7)	37 (3.2)	Ref		0.657 (0.425–1.016)	0.059	1.046 (0.875–1.25)	0.624	0.981 (0.844–1.140)	0.803	0.981 (0.842–1.142)	0.801
	T/C	293 (28.1)	361 (31.6)	0.613 (0.389–0.965)	0.034
	C/C	664 (63.7)	739 (64.7)	0.678 (0.437–1.053)	0.084

OR: odds ratio; CI: confidence interval.