New Personal Model for Forecasting the Outcome of Patients with Histological Grade III-IV Colorectal Cancer Based on Regional Lymph Nodes

Table 2

The univariate and multivariate logistic regression analysis of overall survival in the training cohort.

Variates	Univariate logistic regression analysis				LASSO-logistic regression analysis
	OR	2.5% CI	97.5% CI	value	OR	2.5% CI	97.5% CI	value
Age
<45 years old	Reference				Reference
45–60 years old	1.070	0.921	1.240	0.385	1.222	1.022	1.463	0.029
>60 years old	1.290	1.120	1.490	<0.001	1.994	1.677	2.375	<0.001
Sex
Male	Reference				Reference
Female	0.890	0.820	0.965	0.005	0.859	0.778	0.948	0.003
Race
White	Reference				Reference
Black	1.230	1.080	1.400	0.002	1.242	1.063	1.451	0.006
Other	0.904	0.781	1.050	0.173	0.926	0.776	1.103	0.389
Primary site
Left colon	Reference				Reference
Right colon	1.180	1.070	1.300	0.001	1.302	1.152	1.473	<0.001
Rectum	0.812	0.717	0.918	0.001	1.119	0.964	1.300	0.140
Pathology grade
Grade III	Reference
Grade IV	1.270	1.140	1.410	<0.001
AJCC T stage
T1	Reference				Reference
T2	1.540	1.100	2.140	0.012	1.403	0.993	2.002	0.058
T3	4.420	3.350	5.840	<0.001	2.391	1.789	3.251	<0.001
T4	14.100	10.700	18.700	<0.001	5.145	3.821	7.046	<0.001
AJCC N stage
N0	Reference				Reference
N1	2.630	2.350	2.950	<0.001	0.963	0.788	1.176	0.714
N2	6.720	6.020	7.510	<0.001	1.018	0.796	1.302	0.884
AJCC M stage
M0	Reference				Reference
M1	9.470	8.470	10.600	<0.001	3.674	3.068	4.412	<0.001
Histological type
Adenocarcinoma	Reference				Reference
AM/MPA	1.510	1.310	1.730	<0.001	1.214	1.029	1.432	0.021
SRCC	2.220	1.830	2.690	<0.001	1.637	1.301	2.061	<0.001
LNR
Low	Reference				Reference
High	5.470	4.990	6.000	<0.001	1.174	0.609	2.241	0.629
LODDS
LODDS1	Reference				Reference
LODDS2	2.630	2.340	2.950	<0.001	1.897	1.553	2.32	<0.001
LODDS3	9.400	8.370	10.600	<0.001	3.092	1.587	6.078	0.001
Examined lymph nodes
Low	Reference
High	0.563	0.494	0.641	<0.001
Negative lymph nodes
Low	Reference				Reference
High	0.225	0.203	0.248	<0.001	0.583	0.505	0.674	<0.001
Metastasis at bone
No	Reference				Reference
Yes	38.700	12.200	123.000	<0.001	5.852	2.110	24.349	0.003
Metastasis at brain
No	Reference
Yes	6.370	2.600	15.600	<0.001
Metastasis at liver
No	Reference
Yes	8.430	7.350	9.670	<0.001
Metastasis at lung
No	Reference				Reference
Yes	6.880	5.100	9.290	<0.001	1.794	1.439	2.234	<0.001

AJCC, American Joint Committee on Cancer; T, tumor; N, nodes; M, metastasis; LNR, Lymph node ratio; AM/MPA, mucinous adenocarcinoma\mucin-producing adenocarcinoma; SRCC, signet ring cell carcinoma; OR, odds ratio; CI, confidence interval.