New Personal Model for Forecasting the Outcome of Patients with Histological Grade III-IV Colorectal Cancer Based on Regional Lymph Nodes

Table 3

The univariate and multivariate Cox regression analysis of overall survival in the training cohort.

Variates	Univariate Cox				Multivariate Cox
	HR	95% CI		value	HR	95% CI		value
Age
<45 years old	Reference
45–60 years old	1.060	0.942	1.190	0.330
>60 years old	1.230	1.100	1.370	<0.001
Sex
Male	Reference
Female	0.903	0.848	0.963	0.002
Race
White	Reference				Reference
Black	1.140	1.030	1.260	0.010	1.126	1.020	1.242	0.018
Other	0.941	0.839	1.050	0.295	0.839	0.749	0.941	0.003
Primary site
Left colon	Reference
Right colon	1.160	1.070	1.250	<0.001
Rectum	0.845	0.765	0.933	0.001
AJCC T stage
T1	Reference				Reference
T2	1.140	0.844	1.530	0.399	1.083	0.804	1.459	0.599
T3	3.090	2.420	3.930	<0.001	1.839	1.441	2.348	<0.001
T4	7.630	5.990	9.720	<0.001	3.031	2.367	3.88	<0.001
AJCC M stage
M0	Reference				Reference
M1	5.300	4.960	5.660	<0.001	2.464	2.236	2.715	<0.001
Histological type
Adenocarcinoma	Reference				Reference
AM/MPA	1.310	1.180	1.450	<0.001	1.077	0.971	1.195	0.159
SRCC	1.950	1.720	2.210	<0.001	1.498	1.315	1.707	<0.001
NLNs
Low	Reference
High	0.316	0.296	0.338	<0.001
LODDS
LODDS1	Reference				Reference
LODDS2	2.250	2.030	2.490	<0.001	1.719	1.551	1.905	<0.001
LODDS3	6.260	5.700	6.870	<0.001	3.402	3.077	3.761	<0.001
Metastasis at liver
No	Reference				Reference
Yes	4.440	4.140	4.760	<0.001	1.366	1.236	1.510	<0.001
Metastasis at bone
No	Reference				Reference
Yes	7.030	5.520	8.970	<0.001	2.253	1.763	2.880	<0.001

AJCC, American Joint Committee on Cancer; T, tumor; M, metastasis; LODDS, the log odds of positive lymph nodes; AM/MPA, mucinous adenocarcinoma\mucin-producing adenocarcinoma; SRCC, signet ring cell carcinoma; NLN, negative regional lymph nodes; HR, hazard ratio; CI, confidence interval.