M6A Promotes Colorectal Cancer Progression via Regulating the miR-27a-3p/BTG2 Pathway

<div>YTHDF2 increased degradation of m6A-methylated ADAMTS9-AS2 in CRC cells. FTO or pcDNA were transfected to HCT116 and SW480. (a) The enrichment of m6A-modified ADAMTS9-AS2 was measured using a MeRIP-qPCR experiment. (b) ADAMTS9-AS2 levels. (c, d) The endogenous combination of ADAMTS9-AS2 and YTHDF2 was measured by RIP and qPCR. (e, f) RNA pull-down confirmed that YTHDF2 recognized ADAMTS9-AS2. 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Journal of Oncology

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Figure 4

Figure 4: M6A Promotes Colorectal Cancer Progression via Regulating the miR-27a-3p/BTG2 Pathway 