Exosome-Encapsulated miR-31, miR-192, and miR-375 Serve as Clinical Biomarkers of Gastric Cancer

Table 3

Univariate and multivariate cox analyses for OS in GC patients.

Variables	Univariate analysis		Multivariate analysis
	HR (95% CI)	value	HR (95% CI)	value
Age	0.753; (0.356–1.592)	0.458
<60 vs. ≥60 years
Gender	0.903; (0.432–1.886)	0.786
Male vs. female
Vascular invasion	0.718; (0.358–1.438)	0.350
Absent vs. present
TNM stage	0.281; (0.120–0.655)	0.003	0.174; (0.071–0.425)	<0.001
I + II vs. III + IV
Neural invasion	0.742; (0.373–1.476)	0.395
Absent vs. present
Ex-miR-31 expression	0.447; (0.220–0.908)	0.026	1.892; (0.561–6.377)	0.304
Low vs. high
Ex-miR-192 expression	0.555; (0.272–1.130)	0.104
Low vs. high
Ex-miR-375 expression	0.306; (0.146–0.638)	0.002	0.104; (0.028–0.389)	0.001
Low vs. high