The Interaction between Four Polymorphisms and Haplotype of ABCB1, the Risk of Non-Small Cell Lung Cancer, and the Disease Phenotype

Table 2

Genotype distribution and allele frequencies of ABCB1 SNPs in non-small cell lung carcinoma (NSCLC) patients and control subjects.

ABCB1
SNPs ID		Genotype				Allele
		WT	HET	MUT	value	WT	MUT	value
T-129C	Study	76 (95.0%)	4 (5.0%)	0 (0.0%)	0.8970	156 (97.5%)	4 (2.5%)	0.8175
	Control	90 (95.7%)	4 (4.3%)	0 (0.0%)		184 (97.9%)	4 (2.1%)
	OR (95%Cl)	HET: 1.18 (0.29–4.90)			0.8154	MUT: 1.18 (0.29–4.79)
		MUT: NA			NA
C1236T	Study	30 (37.5%)	29 (36.3%)	21 (26.2%)	0.0223	89 (55.6%)	71 (44.4%)	0.7535
	Control	28 (29.2%)	54 (56.3%)	14 (14.5%)		110 (57.3%)	82 (42.7%)
	OR (95% CI)	HET: 0.50 (0.25-0.99)			0.0480	MUT: 1.07 (0.70–1.63)
		MUT: 1.40 (0.60–3.28)			0.4379
G2677T/A	Study	25 (32.1%)	33 (42.3%)	20 (25.6%)	0.1116	83 (53.2%)	73 (46.8%)	0.2104
	Control	32 (33.4%)	51 (53.1%)	13 (13.5%)		115 (59.9%)	77 (40.1%)
	OR (95% CI)	HET: 0.83 (0.42–1.64)			0.5882	1.31 (0.86–2.01)
		MUT: 1.97 (0.82–4.71)			0.1280
C3435T	Study	11 (13.7%)	41 (51.3%)	28 (35.0%)	0.0319	63 (39.4%)	97 (60.6%)	0.0103
	Control	27 (28.1%)	48 (50.0%)	21 (21.9%)		102 (53.1%)	90 (46.9%)
	OR (95% CI)	HET: 2.10 (0.93–4.74)			0.0752	1.75 (1.14–2.67)
		MUT: 3.27 (1.33-8.06)			0.0099

Frequencies taken from publication [8]. indicates statistical significance and bold indicate a significant difference.