Correlation between Macrophage Polarization and PD-L1-Related Tumor Microenvironmental Alteration and Metastasis in Pancreatic Ductal Adenocarcinoma

Table 7

Relationship between E-cadherin, N-cadherin. and clinicopathological parameters in 42 primary tumors of PDAC.

Clinicopathological parameters	E-cadherin		^∗	N-cadherin		^∗	Snail		^∗
	High expression	Low expression		Positive	Negative		High expression	Low expression
Gender			0.890			0.231			0.002
Male	19	3		5	17		5	14
Female	16	4		1	19		17	6
Diameter (cm)			0.765			1.000			0.936
≤4	25	4		4	25		13	16
>4	10	3		2	11		6	1
Grade			1.000			0.037			0.226
High/Moderate	17	3		0	20		11	9
Poor	18	4		6	16		8	14
Vein invasion			0.320			0.476			0.987
Yes	20	6		5	21		7	9
No	15	1		1	15		11	14
Perineural invasion			0.167			1.000			0.452
Yes	35	6		6	35		18	23
No	0	1		0	1		1	0
TNM stage			0.118			1.000			0.047
I-II	24	2		4	22		9	17
III-IV	11	5		2	14		10	5
Elevated serum CA199			0.532			0.474			1.000
Yes	32	6		5	33		17	21
No	3	1		1	3		2	2
Elevated serum CA125			0.306			0.019			0.273
Yes	10	4		5	9		8	6
No	25	3		1	27		11	17

Bold values indicate statistically significant correlations with values less than 0.05. ^∗Chi-square test and Fisher’s exact test.