Plumbagin Enhances the Anticancer Effects of PF Chemotherapy via Downregulation of the PI3K/AKT/mTOR/p70S6K Pathway in Human Tongue Squamous Cell Carcinoma

<div>Viability of TSCC cells after various treatments. (a-c) Inhibition of the proliferation of Cal27 and Cal27/CDDP cells following treatment with PB, 5-Fu, and CDDP. (d) A combination of PB and PF exerted synergistic cytotoxic effects in Cal27 and Cal27/CDDP cells. TSCC, tongue squamous cell carcinoma; PB, plumbagin; 5-Fu, 5-fluorouracil; and PF, cisplatin plus 5-fluorouracil.</div>

Journal of Oncology

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Figure 1

Figure 1: Plumbagin Enhances the Anticancer Effects of PF Chemotherapy via Downregulation of the PI3K/AKT/mTOR/p70S6K Pathway in Human Tongue Squamous Cell Carcinoma 

Figure 1 | Plumbagin Enhances the Anticancer Effects of PF Chemotherapy via Downregulation of the PI3K/AKT/mTOR/p70S6K Pathway in Human Tongue Squamous Cell Carcinoma 