Plumbagin Enhances the Anticancer Effects of PF Chemotherapy via Downregulation of the PI3K/AKT/mTOR/p70S6K Pathway in Human Tongue Squamous Cell Carcinoma

<div>PB enhanced the proapoptotic effects of PF in TSCC cells. (a) Results of the flow cytometry assay demonstrated apoptosis in Cal27 and Cal27/CDDP cells following the treatment with PB and/or PF. (b-c) A histogram of the levels of apoptosis in Cal27 and Cal27/CDDP cells. (d) Representative blots of the proapoptotic protein Bax and Bad and antiapoptotic protein Bcl-2 and Bcl-xL in Cal27 and Cal27/CDDP cells after the treatment of PB and/or PF. (e) Ratio of Bax/Bcl-2 in Cal27 and Cal27/CDDP cells. (f-g) Histogram of the expression levels of Bcl-xL and Bad. 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Journal of Oncology

fig5

Figure 5

Figure 5: Plumbagin Enhances the Anticancer Effects of PF Chemotherapy via Downregulation of the PI3K/AKT/mTOR/p70S6K Pathway in Human Tongue Squamous Cell Carcinoma 

Figure 5 | Plumbagin Enhances the Anticancer Effects of PF Chemotherapy via Downregulation of the PI3K/AKT/mTOR/p70S6K Pathway in Human Tongue Squamous Cell Carcinoma 