Plumbagin Enhances the Anticancer Effects of PF Chemotherapy via Downregulation of the PI3K/AKT/mTOR/p70S6K Pathway in Human Tongue Squamous Cell Carcinoma

<div>Combined PB and PF inhibited the PI3K/AKT/mTOR/p70S6K pathway in TSCC cells. (a) Representative blots demonstrating the expression of proteins involved in the PI3K/AKT/mTOR pathway in Cal27 and Cal27/CDDP cells following treatment with PB and/or PF. (b–e) A histogram demonstrating the expression level of PI3K, p-AKT/AKT, p-mTOR/mTOR, and p-p70S6K/p70S6K. 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Journal of Oncology

fig6

Figure 6

Figure 6: Plumbagin Enhances the Anticancer Effects of PF Chemotherapy via Downregulation of the PI3K/AKT/mTOR/p70S6K Pathway in Human Tongue Squamous Cell Carcinoma 

Figure 6 | Plumbagin Enhances the Anticancer Effects of PF Chemotherapy via Downregulation of the PI3K/AKT/mTOR/p70S6K Pathway in Human Tongue Squamous Cell Carcinoma 