GINS2 Promotes Osteosarcoma Tumorigenesis via STAT3/MYC Axis

<div>Co-IP and LC-MS identified the downstream interacting protein STAT3 and rescue experiments indicated that overexpressed STAT3 can restore the effect caused by knocking out GINS2. (a) The 3 × Flag-GINS2 interacting complex was purified using the anti-FLAG magnetic beads (red arrow: 3 × FLAG-GINS2). (b) Interaction between GINS2 and STAT3 was confirmed in HOS cells by Co-IP/immunoblotting. (c, d) HCS analysis of the effect of overexpression of STAT3 on the proliferation of HOS cells. (e) The Transwell experiment analyzes the effect of overexpression of STAT3 on HOS cell migration. 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Journal of Oncology

GINS2 Promotes Osteosarcoma Tumorigenesis via STAT3/MYC Axis

Figure 7