Ubiquitin-Specific Peptidase 8 Modulates Cell Proliferation and Induces Cell Cycle Arrest and Apoptosis in Breast Cancer by Stabilizing Estrogen Receptor Alpha

Figure 1

USP8 expression in samples and its correlation with survival, clinicopathological staging characteristics, and target gene expressions in BC patients. (a) USP8 upregulation in BC samples of CPTAC. (b–d) Downregulation of USP8 correlates with poor endocrine treatment outcomes in TCGA dataset. (e–h) The correlation of USP8 expression with clinicopathological characteristics. (i) Immunohistochemical results of patients with different subtypes of BC are shown at 100x magnification. (j) Expression levels of USP8 in different BC cells in the CCLE database. (k) Expression levels of USP8 in 10 BC cell lines. (l) mRNA expression levels of USP8 in 10 BC cell lines. (m) Pearson’s correlation of USP8 expression with ERα, PS2, GREB1, CCND1, PDZK1, BAX, BCL2, CDK2, CDK4, and CDK6 expression.

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