Ubiquitin-Specific Peptidase 8 Modulates Cell Proliferation and Induces Cell Cycle Arrest and Apoptosis in Breast Cancer by Stabilizing Estrogen Receptor Alpha

Figure 2

TIC profile in BC samples and correlation of the proportion of TICs with USP8 expression. (a) Bar plot showing the proportions of 22 types of TICs in BC samples. Column name = sample ID. (b) Heatmap showing the correlations between the 22 types of TICs. Numbers within boxes =  value of Pearson’s correlation between two cells. The shadow of each box = correlation value between two cells. (c) Violin plot showing the ratio of differentiation of 22 TIC types between BC samples with low or high USP8 expression relative to the median of USP8 expression level. The Wilcoxon rank sum was applied for testing the significance. (d) Scatter plot of Pearson’s correlations of four types of TICs with USP8 expression based on CIBERSORT (). The blue line = fitted linear model, indicating the proportion of the immune cell type along with USP8 expression. (e) Scatter plot showing Pearson’s correlations of four types of TICs in different classifications of BC with USP8 expression based on TIMER 2.0 ().

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