Cancer-Specific Survival after Limb Salvage versus Amputation in Children and Adolescents with Osteosarcoma: A Population-Based Analysis with Propensity Score Matching

Table 1

Demographic data and baseline characteristics of OS patients of CYA in original and matched cohorts.

	The original cohort				The matched cohort
	LSS group (N = 1222)	Amputation group (N = 408)	value	Overall (N = 1630)	LSS group (N = 384)	Amputation group (N = 384)	value	Overall (N = 768)
Age			0.954				0.83
<15	531 (43.5%)	176 (43.1%)		707 (43.4%)	166 (43.2)	162 (42.2)		328 (42.7%)
15–39	691 (56.5%)	232 (56.9%)		923 (56.6%)	218 (56.8)	222 (57.8)		440 (57.3%)
Sex			<0.001				0.94
Female	557 (45.6%)	156 (38.2%)		713 (43.7%)	143 (37.2)	145 (37.8)		288 (37.5%)
Male	665 (54.4%)	252 (61.8%)		917 (56.3%)	241 (62.8)	239 (62.2)		480 (62.5%)
Race			0.341				0.85
White	908 (74.3%)	306 (75.0%)		1214 (74.5%)	295 (76.8)	298 (77.6)		593 (77.2%)
Black	189 (15.5%)	53 (13.0%)		242 (14.8%)	39 (10.2)	41 (10.7)		80 (10.4%)
Others	125 (10.2%)	49 (12.0%)		174 (10.7%)	50 (13.0)	45 (11.7)		95 (12.4%)
Primary site			<0.001				0.68
Upper	193 (15.8%)	62 (15.2%)		255 (15.6%)	69 (18.0)	60 (15.6)		129 (16.8%)
Lower	999 (81.8%)	314 (77.0%)		1313 (80.6%)	299 (77.9)	308 (80.2)		607 (79.0%)
Pelvic	30 (2.5%)	32 (7.8%)		62 (3.8%)	16 (4.2)	16 (4.2)		32 (4.2%)
Histology			0.045				1.00
Conventional	1008 (82.5%)	354 (86.8%)		1362 (83.6%)	334 (87.0)	335 (87.2)
Others	214 (17.5%)	54 (13.2%)		268 (16.4%)	50 (13.0)	49 (12.8)		99 (12.9%)
AJCC stage			<0.001				0.99
I	154 (12.6%)	37 (9.1%)		191 (11.7%)	33 (8.6)	34 (8.9)		67 (8.7%)
II	809 (66.2%)	233 (57.1%)		1042 (63.9%)	229 (59.6)	224 (58.3)		453 (59.0%)
III	23 (1.9%)	13 (3.2%)		36 (2.2%)	8 (2.1)	8 (2.1)		16 (2.1%)
IV	236 (19.3%)	125 (30.6%)		361 (22.1%)	114 (29.7)	118 (30.7)		232 (30.2%)
Chemotherapy			0.115				0.52
No/unknown	106 (8.7%)	25 (6.1%)		131 (8.0%)	18 (4.7)	23 (6.0)		41 (5.3%)
Yes	1116 (91.3%)	383 (93.9%)		1499 (92.0%)	366 (95.3)	361 (94.0)		727 (94.7%)