Cancer-Specific Survival after Limb Salvage versus Amputation in Children and Adolescents with Osteosarcoma: A Population-Based Analysis with Propensity Score Matching

Table 2

Univariate and multivariate Cox regression analysis for OS in the original cohort.

Characteristics	The univariate analysis			The multivariate analysis
	HR	CI.95	value	HR	CI.95	value
Age
<15	Reference
15–39	1.2	0.99–1.45	0.059
Chemotherapy
No/Unknown	Reference			Reference
Yes	2.77	1.66–4.64	<0.001	1.2	0.65–2.2	0.5597
Histology
Conventional	Reference			Reference
Others	0.45	0.31–0.59	<0.001	0.57	0.4–0.79	0.001
Primary site
Upper	Reference			Reference
Lower	0.83	0.64–1.06	0.135	0.85	0.66–1.1	0.2148
Pelvic	1.94	1.27–2.97	0.002	1.91	1.24–2.95	0.0035
Race
White	Reference
Black	1.21	0.94–1.56	0.135
Others	1.15	0.85–1.55	0.367
Sex
Female	Reference			Reference
Male	1.28	1.06–1.55	0.01	1.22	1.01–1.48	0.04
Stage
I	Reference			Reference
II	2.46	1.43–4.23	0.001	1.71	0.91–3.23	0.0951
III	9.04	4.59–17.77	<0.001	6.5	3.09–13.68	<0.001
IV	9.07	5.27–15.61	<0.001	6.05	3.19–11.44	<0.001
Surgery
Amputation	Reference			Reference
LSS	0.54	0.45–0.66	<0.001	0.66	0.54–0.8	<0.001